{"id":9229,"date":"2022-05-11T14:48:19","date_gmt":"2022-05-11T12:48:19","guid":{"rendered":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/?p=9229"},"modified":"2022-05-11T14:48:21","modified_gmt":"2022-05-11T12:48:21","slug":"brain-and-retinal-organoids-for-disease-modeling-the-importance-of-in-vitro-blood-brain-and-retinal-barriers-studies","status":"publish","type":"post","link":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/brain-and-retinal-organoids-for-disease-modeling-the-importance-of-in-vitro-blood-brain-and-retinal-barriers-studies\/","title":{"rendered":"Brain and Retinal Organoids for Disease Modeling: The Importance of In Vitro Blood\u2013Brain and Retinal Barriers Studies"},"content":{"rendered":"\n<p><em>Ilenia Martinelli, Seyed Khosrow Tayebati, Daniele Tomassoni, Giulio Nittari, Proshanta Roy, Francesco Amenta<\/em>.<\/p>\n\n\n\n<p>Academic Editor: Stefan Liebau<br><em>Cells <\/em><strong>2022<\/strong>,\u00a0<em>11<\/em>(7), 1120; <a rel=\"noreferrer noopener\" href=\"https:\/\/www.mdpi.com\/2073-4409\/11\/7\/1120\/htm\" target=\"_blank\">Link<\/a><\/p>\n\n\n\n<p>Una pubblicazione scientifica realizzata nell\u2019ambito del progetto Marchebiobank, dall\u2019Universit\u00e0 di Camerino.<\/p>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p>Brain and retinal organoids are functional and dynamic in vitro three-dimensional (3D) structures derived from pluripotent stem cells that spontaneously organize themselves to their in vivo counterparts. Here, we review the main literature data of how these organoids have been developed through different protocols and how they have been technically analyzed. Moreover, this paper reviews recent advances in using organoids to model neurological and retinal diseases, considering their potential for translational applications but also pointing out their limitations. Since the blood\u2013brain barrier (BBB) and blood\u2013retinal barrier (BRB) are understood to play a fundamental role respectively in brain and eye functions, both in health and in disease, we provide an overview of the progress in the development techniques of in vitro models as reliable and predictive screening tools for BBB and BRB-penetrating compounds. Furthermore, we propose potential future directions for brain and retinal organoids, in which dedicated biobanks will represent a novel tool for neuroscience and ophthalmology research.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-file\"><a href=\"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-content\/uploads\/2022\/05\/Brain-and-retinal-organoids-for-disease-modeling-2022.pdf\">Brain-and-retinal-organoids-for-disease-modeling-2022<\/a><a href=\"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-content\/uploads\/2022\/05\/Brain-and-retinal-organoids-for-disease-modeling-2022.pdf\" class=\"wp-block-file__button\" download>Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ilenia Martinelli, Seyed Khosrow Tayebati, Daniele Tomassoni, Giulio Nittari, Proshanta Roy, Francesco Amenta. Academic Editor: Stefan LiebauCells 2022,\u00a011(7), 1120; Link Una pubblicazione scientifica realizzata nell\u2019ambito del progetto Marchebiobank, dall\u2019Universit\u00e0 di Camerino. Abstract Brain and retinal organoids are functional and dynamic in vitro three-dimensional (3D) structures derived from pluripotent stem cells that spontaneously organize themselves to &hellip; <a href=\"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/brain-and-retinal-organoids-for-disease-modeling-the-importance-of-in-vitro-blood-brain-and-retinal-barriers-studies\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Brain and Retinal Organoids for Disease Modeling: The Importance of In Vitro Blood\u2013Brain and Retinal Barriers Studies<\/span><\/a><\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":true,"template":"","format":"standard","meta":[],"categories":[245],"tags":[253,252,251,228,250,239,254,255],"_links":{"self":[{"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/posts\/9229"}],"collection":[{"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/comments?post=9229"}],"version-history":[{"count":2,"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/posts\/9229\/revisions"}],"predecessor-version":[{"id":9232,"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/posts\/9229\/revisions\/9232"}],"wp:attachment":[{"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/media?parent=9229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/categories?post=9229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.marchebiobank.it\/progetto-regione-marche\/wp-json\/wp\/v2\/tags?post=9229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}